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Version: 17.06d (Release date: 2017-06-26)
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Immunocytokine NHS-IL2-LT (Code C82411)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Immunocytokine NHS-IL2-LT

Definition: A fusion protein consisting of a mouse-human chimeric antibody directed against DNA released by necrotic tumor cells fused to two molecules of a genetically modified human interleukin-2 (IL-2) with potential antineoplastic activity. Upon administration, the antibody moiety of immunocytokine NHS-IL2-LT binds to DNA released by necrotic tumor cells located primarily at the core of necrotic solid tumors, delivering the IL-2 moiety. In turn, the IL-2 moiety of this agent activates the immune system to mount a cytotoxic T lymphocyte response against nearby tumor cells.

Label: Immunocytokine NHS-IL2-LT

NCI Thesaurus Code: C82411 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2830085  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ch.14.18-IL2
EMD 521873
Immunocytokine NHS-IL2-LT
Selectikine

External Source Codes: 
PDQ Closed Trial Search ID 641919
PDQ Open Trial Search ID 641919 (check for NCI PDQ open clinical trial info)
UMLS CUI C2830085

Other Properties:
     Name Value (qualifiers indented underneath)
code C82411
Legacy_Concept_Name Selectikine
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C82411

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