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Version: 17.08d (Release date: 2017-08-28)
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CD34/TK75 Retroviral Vector-Transduced Donor Lymphocytes (Code C82409)

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Terms & Properties

Preferred Name: CD34/TK75 Retroviral Vector-Transduced Donor Lymphocytes

Definition: A preparation of donor T-lymphocytes that are transfected with a retroviral vector encoding a chimeric suicide gene consisting of the extracellular and transmembrane domains of human CD34 and mutant 75 of the herpes simplex virus thymidine kinase (HSV-TK75) with potential controllable immunomodulating activity. Donor T cell therapy following allogeneic hematopoietic stem cell (HSC) transplantation may result in a graft-versus-leukemia (GVL) and help control transplant-related viral infections. In the event that graft-versus-host disease (GVHD) develops due to donor lymphocyte infusion, CD34/TK75-transduced donor lymphocytes may be selectively eliminated by administration of the prodrug antiviral agent ganciclovir GCV. In CD34/T75-transduced donor lymphocytes, GCV is phosphorylated by expressed HSV-TK75 to its monophosphate form and, subsequently, converted into its active triphosphate form, which specifically kills the donor lymphocytes. The expressed CD34 moiety of the chimeric suicide gene serves as a selection marker; mutant 75 of HSV-TK confers increased GCV sensitivity.

Display Name: CD34/TK75 Retroviral Vector-Transduced Donor Lymphocytes

Label: CD34/TK75 Retroviral Vector-Transduced Donor Lymphocytes

NCI Thesaurus Code: C82409 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2826156  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CD34/TK75 Retroviral Vector-Transduced Donor Lymphocytes

External Source Codes: 
PDQ Closed Trial Search ID 640980
PDQ Open Trial Search ID 640980 (check for NCI PDQ open clinical trial info)
UMLS CUI C2826156

Other Properties:
     Name Value (qualifiers indented underneath)
code C82409
Contributing_Source CTRP
Legacy_Concept_Name CD34_TK75_Retroviral_Vector-Transduced_Donor_Lymphocytes
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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