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Version: 17.08d (Release date: 2017-08-28)
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2G-1 TCR Retroviral Vector-Transduced Lymphocytes (Code C82408)

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Terms & Properties

Preferred Name: 2G-1 TCR Retroviral Vector-Transduced Lymphocytes

Definition: A preparation of autologous human T-lymphocytes isolated from renal cell cancer (RCC) patient and transduced with 2G-1 TCR, a retroviral vector encoding the alpha and beta chains of a T-cell receptor that recognizes TNF-related apoptosis inducing ligand (TRAIL) bound to death receptor 4 (DR4), with potential immunostimulating and antineoplastic activities. After transduction, expansion in culture, and introduction into the RCC patient, 2G-1 TCR retroviral vector-transduced lymphocytes may stimulate a cytotoxic T lymphocyte (CTL) response against RCC cells with TRAIL bound to DR4 on their surfaces. TRAIL, a member of the TNF superfamily, is a homotrimeric type II membrane protein that rapidly induces oligomerization of receptor intracellular death domains and apoptosis in a variety of tumor cells when bound to its receptors; DR4 (TRAIL receptor 1), a member of the TNF receptor family, is overexpressed by a variety of malignant cell types.

Label: 2G-1 TCR Retroviral Vector-Transduced Lymphocytes

NCI Thesaurus Code: C82408 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL408672  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2G-1 TCR Retroviral Vector-Transduced Lymphocytes
PG13-A(F/K)-F-SGSG-T2a-B(opt)(2G-1 TCR) Retroviral Vector-Transduced Lymphocytes

External Source Codes: 
PDQ Closed Trial Search ID 639521
PDQ Open Trial Search ID 639521 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C82408
Legacy_Concept_Name _2G-1_TCR_Retroviral_Vector-Transduced_Lymphocytes
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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