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Version: 17.06d (Release date: 2017-06-26)
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PIM Kinase Inhibitor SGI-1776 (Code C82404)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: PIM Kinase Inhibitor SGI-1776

Definition: A small-molecule pan-PIM protein kinase inhibitor with potential antineoplastic activity. PIM kinase inhibitor SGI-1776 binds to and inhibits the activities of PIM-1, -2 and -3 serine/threonine kinases, which may result in the interruption of the G1/S phase cell cycle transition, the expression of pro-apoptotic Bcl2 proteins and tumor cell apoptosis. PIM kinases play key roles in cell cycle progression and apoptosis inhibition and may be overexpressed in various malignancies.

Display Name: PIM Kinase Inhibitor SGI-1776

Label: PIM Kinase Inhibitor SGI-1776

NCI Thesaurus Code: C82404 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2742218  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
PIM Kinase Inhibitor SGI-1776
SGI-1776

External Source Codes: 
PDQ Closed Trial Search ID 638088
PDQ Open Trial Search ID 638088 (check for NCI PDQ open clinical trial info)
UMLS CUI C2742218

Other Properties:
     Name Value (qualifiers indented underneath)
code C82404
Contributing_Source CTRP
Legacy_Concept_Name Pim_Kinase_Inhibitor_SGI-1776
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C82404

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