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Version: 17.06d (Release date: 2017-06-26)
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Sizofiran (Code C824)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Sizofiran

Definition: A soluble beta-D-glucan produced by the Basidiomycetes fungus, Schizophyllum commune Fries, with potential immunomodulating and antitumor activities. Although sizofiran's exact mechanism of action has yet to be fully elucidated, this agent appears to stimulate the immune system by increasing cytokine production, activating macrophages and enhancing the activity of polymorphonuclear leukocytes (PML) and natural killer (NK) cells.

Label: Sizofiran

NCI Thesaurus Code: C824 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0036359  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
MC-Glucan
Poly(3-(O-beta-D-glucopyranosyl-(1-3)-O-(beta-D-glucopyranosyl-(1-6))-O-beta-D-glucopyranosyl-(1-3)-O-beta-D-glucopyranosyl)-1)
Schizophyllan
Schizophyllane
Sixofilan
Sizofiran
SIZOFIRAN
Sonifilan

External Source Codes: 
CAS Registry Number 9050-67-3 (see NLM ChemIDplus info)
FDA UNII Code 7F763NNC9X
ChEBI ID CHEBI:50653 (see ChEBI info)
PDQ Closed Trial Search ID 752996
PDQ Open Trial Search ID 752996 (check for NCI PDQ open clinical trial info)
UMLS CUI C0036359

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula (C24H38O19)n
code C824
Contributing_Source FDA
Legacy_Concept_Name Sizofiran
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C824

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