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Version: 16.11d (Release date: 2016-11-28)
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Anti-KSP/Anti-VEGF siRNAs ALN-VSP02 (Code C82391)

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Terms & Properties

Preferred Name: Anti-KSP/Anti-VEGF siRNAs ALN-VSP02

Definition: A lipid nanoparticle formulation containing two small interfering RNAs (siRNAs) for kinesin spindle protein (KSP) and vascular endothelial growth factor (VEGF) with potential antitumor activity. Upon intravenous administration, the siRNAs in KSP/VEGF siRNAs ALN-VSP02ALN bind to both KSP and VEGF messenger RNAs (mRNAs), preventing translation of KSP and VEGF proteins; this may result in growth inhibition of tumor cells that overexpress KSP and VEGF. VEGF and KSP are upregulated in many tumor cells and play an important role in tumor proliferation and survival.

Display Name: Anti-KSP/Anti-VEGF siRNAs ALN-VSP02

Label: Anti-KSP/Anti-VEGF siRNAs ALN-VSP02

NCI Thesaurus Code: C82391 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL408662  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ALN-VSP02
Anti-KSP/Anti-VEGF siRNAs ALN-VSP02

External Source Codes: 
PDQ Closed Trial Search ID 642288
PDQ Open Trial Search ID 642288 (check for NCI PDQ open clinical trial info)
NCI META CUI CL408662

Other Properties:
Name Value (qualifiers indented underneath)
code C82391
Contributing_Source CTRP
Legacy_Concept_Name Anti-KSP_Anti-VEGF_siRNAs_ALN-VSP02
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C82391

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