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Version: 16.10e (Release date: 2016-10-31)
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Afuresertib (Code C82390)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Afuresertib

Definition: An orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Afuresertib binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

Display Name: Afuresertib

Label: Afuresertib

NCI Thesaurus Code: C82390 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2830073  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Afuresertib
GSK2110183

External Source Codes: 
PDQ Closed Trial Search ID 642287
PDQ Open Trial Search ID 642287 (check for NCI PDQ open clinical trial info)
UMLS CUI C2830073

Other Properties:
Name Value (qualifiers indented underneath)
code C82390
Contributing_Source CTRP
Legacy_Concept_Name Oral_Akt_Inhibitor_GSK2110183
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C82390

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