skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Hsp90 Inhibitor HSP990 (Code C82387)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Hsp90 Inhibitor HSP990

Definition: An orally bioavailable inhibitor of human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp90 inhibitor Hsp990 binds to and inhibits the activity of Hsp90, which may result in the proteasomal degradation of oncogenic client proteins, including HER2/ERBB2, and the inhibition of tumor cell proliferation. Hsp90, upregulated in a variety of tumor cells, is a molecular chaperone that plays a key role in the conformational maturation, stability and function of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules that are important in cell cycle regulation and/or immune responses.

Label: Hsp90 Inhibitor HSP990

NCI Thesaurus Code: C82387 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL408658  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Hsp90 Inhibitor HSP990
HSP990

External Source Codes: 
PDQ Closed Trial Search ID 641983
PDQ Open Trial Search ID 641983 (check for NCI PDQ open clinical trial info)
NCI META CUI CL408658

Other Properties:
     Name Value (qualifiers indented underneath)
code C82387
Legacy_Concept_Name Oral_Hsp90_Inhibitor_HSP990
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C82387

Mainbox Bottom