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Version: 16.11d (Release date: 2016-11-28)
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Dabrafenib (Code C82386)

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Terms & Properties

Preferred Name: Dabrafenib

Definition: An orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations.

Display Name: Dabrafenib

Label: Dabrafenib

NCI Thesaurus Code: C82386 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3467876  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Benzenesulfonamide, N-(3-(5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl)-2-fluorophenyl)-2,6-difluoro-
BRAF Inhibitor GSK2118436
Dabrafenib
DABRAFENIB
GSK-2118436A
GSK2118436

External Source Codes: 
CAS Registry Number 1195765-45-7 (see NLM ChemIDplus info)
FDA UNII Code QGP4HA4G1B
PDQ Closed Trial Search ID 641977
PDQ Open Trial Search ID 641977 (check for NCI PDQ open clinical trial info)
UMLS CUI C3467876

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C23H20F3N5O2S2
code C82386
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name BRAF_Inhibitor_GSK2118436
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C82386

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