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Version: 17.06d (Release date: 2017-06-26)
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Gamma Secretase Inhibitor PF-03084014 (Code C82383)

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Terms & Properties

Preferred Name: Gamma Secretase Inhibitor PF-03084014

Definition: A selective gamma secretase (GS) inhibitor with potential antitumor activity. Gamma secretase inhibitor PF-03084014 binds to GS, blocking proteolytic activation of Notch receptors; Notch signaling pathway inhibition may follow, which may result in the induction of apoptosis in tumor cells that overexpress Notch. The integral membrane protein GS is a multi-subunit protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors, at residues within their transmembrane domains. Overexpression of the Notch signaling pathway has been correlated with increased tumor cell growth and survival.

Display Name: Gamma Secretase Inhibitor PF-03084014

Label: Gamma Secretase Inhibitor PF-03084014

NCI Thesaurus Code: C82383 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2830067  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Gamma Secretase Inhibitor PF-03084014
PF-03084014

External Source Codes: 
PDQ Closed Trial Search ID 641472
PDQ Open Trial Search ID 641472 (check for NCI PDQ open clinical trial info)
UMLS CUI C2830067

Other Properties:
     Name Value (qualifiers indented underneath)
code C82383
Contributing_Source CTRP
Legacy_Concept_Name Gamma_Secretase_Inhibitor_PF-03084014
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C82383

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