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Version: 17.06d (Release date: 2017-06-26)
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Lurbinectedin (Code C82382)

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Terms & Properties

Preferred Name: Lurbinectedin

Definition: A synthetic tetrahydropyrrolo [4, 3, 2-de]quinolin-8(1H)-one alkaloid analogue with potential antineoplastic activity. Lurbinectedin covalently binds to residues lying in the minor groove of DNA, which may result in delayed progression through S phase, cell cycle arrest in the G2/M phase and cell death.

Display Name: Lurbinectedin

Label: Lurbinectedin

NCI Thesaurus Code: C82382 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2830066  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
PDQ Closed Trial Search ID 641468
PDQ Open Trial Search ID 641468 (check for NCI PDQ open clinical trial info)
UMLS CUI C2830066

Other Properties:
     Name Value (qualifiers indented underneath)
code C82382
Contributing_Source CTRP
Legacy_Concept_Name DNA_Minor_Groove_Binding_Agent_PM01183
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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