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Version: 17.06d (Release date: 2017-06-26)
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PI3K Inhibitor GDC-0941 Bismesylate (Code C82380)

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Terms & Properties

Preferred Name: PI3K Inhibitor GDC-0941 Bismesylate

Definition: The orally bioavailable bismesylate salt of a potent small-molecule thieno[3,2-d]pyrimidine inhibitor of the class I phosphatidylinositol 3 kinase (PI3K) isoforms p100alpha and p100delta with potential antineoplastic activity. PI3K inhibitor GDC-0941 selectively binds to PI3K isoforms in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K/Akt signaling pathway; inhibition of tumor cell growth, motility and survival in susceptible tumor cell populations may result. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis; dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

Display Name: PI3K Inhibitor GDC-0941 Bismesylate

Label: PI3K Inhibitor GDC-0941 Bismesylate

NCI Thesaurus Code: C82380 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL408651  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1- ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine, bimesylate salt
GDC-0941 Bismesylate
PI3K Inhibitor GDC-0941 Bismesylate

External Source Codes: 
PDQ Closed Trial Search ID 641462
PDQ Open Trial Search ID 641462 (check for NCI PDQ open clinical trial info)
NCI META CUI CL408651

Other Properties:
     Name Value (qualifiers indented underneath)
code C82380
Contributing_Source CTRP
Legacy_Concept_Name PI3K_Inhibitor_GDC-0941_Bismesylate
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C82380

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