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Version: 16.10e (Release date: 2016-10-31)
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Pan-VEGFR/TIE2 Tyrosine Kinase Inhibitor CEP-11981 (Code C82379)

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Terms & Properties

Preferred Name: Pan-VEGFR/TIE2 Tyrosine Kinase Inhibitor CEP-11981

Definition: An orally bioavailable inhibitor of vascular endothelial growth factor receptor (VEGFR) and Tie2 receptor tyrosine kinases with potential antiangiogenic and antineoplastic activities. Pan-VEGFR/Tie2 tyrosine kinase inhibitor CEP-11981 selectively binds to VEGFR and Tie2 receptor tyrosine kinases, which may result in the inhibition of endothelial cell migration, proliferation and survival and the inhibition of tumor cell proliferation and tumor cell death. VEGFR and Tie2 are frequently overexpressed by a variety of tumor cell types and play crucial roles in the regulation of angiogenesis and the maintenance of tumor blood vessels. Tie2 (tyrosine kinase with immunoglobulin-like and EGF-like domains) is activated by angiopoietin-1 (Ang-1).

Display Name: Pan-VEGFR/TIE2 Tyrosine Kinase Inhibitor CEP-11981

Label: Pan-VEGFR/TIE2 Tyrosine Kinase Inhibitor CEP-11981

NCI Thesaurus Code: C82379 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2830064  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CEP-11981
Pan-VEGFR/TIE2 Tyrosine Kinase Inhibitor CEP-11981

External Source Codes: 
PDQ Closed Trial Search ID 641461
PDQ Open Trial Search ID 641461 (check for NCI PDQ open clinical trial info)
UMLS CUI C2830064

Other Properties:
Name Value (qualifiers indented underneath)
code C82379
Contributing_Source CTRP
Legacy_Concept_Name Oral_Pan-VEGFR_TIE2_Tyrosine_Kinase_Inhibitor_CEP-11981
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C82379

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