skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Recombinant Saccharomyces Cerevisia-CEA(610D)-Expressing Vaccine GI-6207 (Code C82371)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Recombinant Saccharomyces Cerevisia-CEA(610D)-Expressing Vaccine GI-6207

Definition: A whole, heat-killed, recombinant Saccharomyces cerevisiae yeast-based vaccine genetically altered to express the carcinoembryonic antigen (CEA) peptide 610D with potential immunostimulating and antineoplastic activities. Upon administration, recombinant Saccharomyces cerevisia-CEA(610D) vaccine GI-6207 may stimulate a host cytotoxic T-lymphocyte (CTL) response against CEA-expressing tumor cells, which may result in tumor cell lysis. CEA, a tumor associated antigen, is overexpressed on a wide variety of human cancer cells including colorectal, gastric, lung, breast and pancreatic cancer cells. CEA 610D encodes for 9 amino acids (605-613) in which aspartate is substituted for asparagine at position 610 (610D) in order to strengthen the induction of the CTL response against CEA-expressing tumor cells.

Display Name: Recombinant Saccharomyces Cerevisia-CEA(610D)-Expressing Vaccine GI-6207

Label: Recombinant Saccharomyces Cerevisia-CEA(610D)-Expressing Vaccine GI-6207

NCI Thesaurus Code: C82371 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2830061  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
GI-6207
Recombinant Saccharomyces Cerevisia-CEA(610D)-Expressing Vaccine GI-6207

External Source Codes: 
PDQ Closed Trial Search ID 641167
PDQ Open Trial Search ID 641167 (check for NCI PDQ open clinical trial info)
UMLS CUI C2830061

Other Properties:
     Name Value (qualifiers indented underneath)
code C82371
Contributing_Source CTRP
Legacy_Concept_Name Recombinant_Saccharomyces_Cerevisia-CEA_610D_Expressing_Vaccine_GI-6207
Semantic_Type Chemical Viewed Functionally

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C82371

Mainbox Bottom