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Version: 17.06d (Release date: 2017-06-26)
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Innate Immunostimulator rBBX-01 (Code C82362)

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Terms & Properties

Preferred Name: Innate Immunostimulator rBBX-01

Definition: A recombinant 19 kDa protein derived from the Apicomplexa protozoan Eimeria with potential immunostimulating and antitumor activities. Upon administration, innate immunostimulator rBBX-01 activates dendritic cells (DCs), stimulates the Toll-like receptor 11 (TLR-11)-mediated release of interleukin-12 (Il-12) from DCs, and induces a T-helper 1 (Th1) type immune response, which may induce an immune response against tumor cells. Infection with Eimeria, a coccidian commonly infecting the intestine, may be negatively correlated with tumorigenesis.

Display Name: Innate Immunostimulator rBBX-01

Label: Innate Immunostimulator rBBX-01

NCI Thesaurus Code: C82362 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL408641  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Innate Immunostimulator rBBX-01

External Source Codes: 
PDQ Closed Trial Search ID 640624
PDQ Open Trial Search ID 640624 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C82362
Contributing_Source CTRP
Legacy_Concept_Name Innate_Immunostimulator_rBBX-01
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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