skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Autologous Prostate Cancer Antigen-expressing Dendritic Cell Vaccine BPX-101 (Code C82361)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Autologous Prostate Cancer Antigen-expressing Dendritic Cell Vaccine BPX-101

Definition: A genetically-modified autologous dendritic cell-based vaccine expressing a drug-inducible costimulatory CD40 receptor (iCD40) with potential immunomodulating and antineoplastic activities. Autologous dendritic cells (DCs) are genetically modified to express the iCD40 receptor and are pulsed with the tumor antigen prostate-specific membrane antigen (PSMA). Upon intradermal administration, these DCs accumulate in local draining lymph nodes. Twenty-four hours after vaccination, the dimerizer agent AP1903 is administered; AP1903 binds to and activates iCD40 receptors presented on DC surfaces, thus activating the DCs and stimulating a cytotoxic T-lymphocyte (CTL) response against host tumor cells that express PSMA. This delayed activation strategy optimizes DC accumulation in local draining lymph nodes prior to DC activation. iCD40 contains a membrane-localized cytoplasmic CD40 domain fused to a drug-binding domain.

Label: Autologous Prostate Cancer Antigen-expressing Dendritic Cell Vaccine BPX-101

NCI Thesaurus Code: C82361 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL408640  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Autologous Prostate Cancer Antigen-expressing Dendritic Cell Vaccine BPX-101
BP-GMAX-CD1
BPX-101

External Source Codes: 
PDQ Closed Trial Search ID 640422
PDQ Open Trial Search ID 640422 (check for NCI PDQ open clinical trial info)
NCI META CUI CL408640

Other Properties:
     Name Value (qualifiers indented underneath)
code C82361
Legacy_Concept_Name iCD40_Receptor_Pulsed_Autologous_Dendritic_Cell_Vaccine_BP-GMAX-CD1
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C82361

Mainbox Bottom