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Version: 17.12d (Release date: 2017-12-26)
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Adecatumumab (Code C82358)

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Terms & Properties

Preferred Name: Adecatumumab

Definition: A recombinant human IgG1 monoclonal antibody (MoAb) directed against the tumor associated antigen (TAA) epithelial cell adhesion molecule (EpCAM) with potential antitumor activity. Adecatumumab binds to EpCAM, which may result in antibody-dependent cellular cytotoxicity (ADCC) directed against EpCAM-expressing tumor cells. EpCAM (CD326), a cell surface protein upregulated on many tumor cell types, promotes the proliferation, migration and invasiveness of tumor cells; for some cancers, overexpression has been correlated with decreased survival.

Label: Adecatumumab

NCI Thesaurus Code: C82358 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1741817  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-EpCAM Monoclonal Antibody MT201

External Source Codes: 
CAS Registry Number 503605-66-1 (see NLM ChemIDplus info)
FDA UNII Code 000705ZASD
PDQ Closed Trial Search ID 640250
PDQ Open Trial Search ID 640250 (check for NCI PDQ open clinical trial info)
UMLS CUI C1741817

Other Properties:
     Name Value (qualifiers indented underneath)
code C82358
Contributing_Source FDA
Legacy_Concept_Name Adecatumumab
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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