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Version: 17.06d (Release date: 2017-06-26)
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Leucine-Enhanced Essential Amino Acid Dietary Supplement (Code C82357)

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Terms & Properties

Preferred Name: Leucine-Enhanced Essential Amino Acid Dietary Supplement

Definition: An orally bioavailable leucine enriched essential amino acid dietary supplement with potential anti-cachexia activity. Leucine-enhanced essential amino acid nutritional supplement may stimulate the mammalian target of rapamycin (mTOR) signaling pathway, which may promote protein synthesis in muscle cells. Although the exact mechanism by which leucine and other essential amino acids stimulate mTOR has yet to be fully elucidated, leucine may stimulate mTOR by inhibiting adenosine monophosphate protein kinase (AMPK), which negatively controls mTOR signaling.

Label: Leucine-Enhanced Essential Amino Acid Dietary Supplement

NCI Thesaurus Code: C82357 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL408637  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Leucine-Enhanced Essential Amino Acids
Leucine-Enhanced Essential Amino Acid Dietary Supplement

External Source Codes: 
PDQ Closed Trial Search ID 640231
PDQ Open Trial Search ID 640231 (check for NCI PDQ open clinical trial info)
NCI META CUI CL408637

Other Properties:
     Name Value (qualifiers indented underneath)
code C82357
Legacy_Concept_Name Leucine-Enhanced_Essential_Amino_Acid_Dietary_Supplement
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C82357

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