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Version: 17.06d (Release date: 2017-06-26)
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Lutetium Lu 177-DOTA-di-HSG Peptide IMP-288 (Code C82354)

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Terms & Properties

Preferred Name: Lutetium Lu 177-DOTA-di-HSG Peptide IMP-288

Definition: A radiolabeled divalent histamine-succinyl-glycine (HSG) hapten-peptide linked with the macrocyclic chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) to the radionuclide lutetium (Lu) 177. After pretargeting with a bispecific monoclonal antibody (BiMoAB) directed against both a tumor associated antigen (TAA) and the HSG hapten-peptide, the HSG portion of administered Lu-177-labeled di-HSG-DOTA peptide IMP-288 binds the anti-HSG portion of the BiMoAB; Lu-177 radioisotopic activity localized to tumor cells bearing the TAA can then be visualized scintigraphically.

Label: Lutetium Lu 177-DOTA-di-HSG Peptide IMP-288

NCI Thesaurus Code: C82354 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL408635  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Lu-177-Labeled Di-Histamine-Succinyl-Glycine-DOTA Peptide IMP-288
Lutetium Lu 177-DOTA-di-HSG Peptide IMP-288

External Source Codes: 
PDQ Closed Trial Search ID 639752
PDQ Open Trial Search ID 639752 (check for NCI PDQ open clinical trial info)
NCI META CUI CL408635

Other Properties:
     Name Value (qualifiers indented underneath)
code C82354
Legacy_Concept_Name Lutetium_Lu_177-DOTA-di-HSG_Peptide_IMP-288
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C82354

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