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Version: 17.12d (Release date: 2017-12-26)
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TLR-Directed Cationic Lipid-DNA Complex JVRS-100 (Code C82353)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: TLR-Directed Cationic Lipid-DNA Complex JVRS-100

Definition: A cationic lipid DNA complex (CLDC) consisting of DOTIM/cholesterol liposomes and plasmid DNA, containing immunostimulatory CpG and non-CpG motifs, with potential immunostimulating and antineoplastic activities. Upon systemic administration, TLR-directed cationic lipid-DNA complex JVRS-100 enters dendritic cells (DCs) and macrophages; immunostimulatory DNA binds to and activates Toll-like receptors (TLRs), which may result in the generation of anti-tumor natural killer (NK) cell and T-cell responses by the innate immune system. In addition, as a vaccine adjuvant, this agent may induce a strong cytotoxic T-lymphocyte (CTL) response to co-administered antigen.

Label: TLR-Directed Cationic Lipid-DNA Complex JVRS-100

NCI Thesaurus Code: C82353 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL408634  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
TLR-Directed Cationic Lipid-DNA Complex JVRS-100
Toll-Like Receptor-Directed Cationic Lipid-DNA Complex JVRS-100

External Source Codes: 
PDQ Closed Trial Search ID 639691
PDQ Open Trial Search ID 639691 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C82353
Legacy_Concept_Name Cationic_Lipid-DNA_Complex_JVRS-100
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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