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Version: 17.06d (Release date: 2017-06-26)
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M87o-Transduced CD34+ Peripheral Blood Stem Cells (Code C82351)

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Terms & Properties

Preferred Name: M87o-Transduced CD34+ Peripheral Blood Stem Cells

Definition: Peripheral blood stem cells (PBSCs) transduced with the retroviral vector M87o encoding for the HIV-1-entry inhibitor peptide membrane-anchored antiviral peptide C46 (maC46). Expression of C46 by M87o-transduced CD34+ peripheral blood stem cells may prevent the fusion of viral and cellular membranes, thereby inhibiting HIV-1 entry. C46 is a membrane-anchored peptide encoding amino acids 628 to 673 of the HIV-1 entry inhibitory transmembrane glycoprotein gp41.

Label: M87o-Transduced CD34+ Peripheral Blood Stem Cells

NCI Thesaurus Code: C82351 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL408632  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
M87o-Transduced CD34+ PBSC
M87o-Transduced CD34+ Peripheral Blood Stem Cells
Therapeutic Gamma-Retroviral Vector M87o-Transduced CD34+ Peripheral Blood Stem Cells

External Source Codes: 
PDQ Closed Trial Search ID 639653
PDQ Open Trial Search ID 639653 (check for NCI PDQ open clinical trial info)
NCI META CUI CL408632

Other Properties:
     Name Value (qualifiers indented underneath)
code C82351
Legacy_Concept_Name M87o-Transduced_CD34_Plus_Peripheral_Blood_Stem_Cells
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C82351

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