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Version: 16.10e (Release date: 2016-10-31)
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Onartuzumab (Code C82348)

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Terms & Properties

Preferred Name: Onartuzumab

Definition: A humanized monovalent monoclonal antibody directed against the hepatocyte growth factor receptor (c-Met) with potential antineoplastic activity. Anti-MET monoclonal antibody MetMAb binds to the extracellular domain of c-Met, preventing the binding of its ligand, hepatocyte growth factor (HGF); the activation of the c-Met signaling pathway is thus inhibited, which may result in cell death in c-Met-expressing tumor cells. c-Met, a receptor tyrosine kinase, is overexpressed on the cell surfaces of a variety of cancer cell types and may play a key role in their proliferation, invasion and survival.

Display Name: Onartuzumab

Label: Onartuzumab

NCI Thesaurus Code: C82348 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2826110  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-MET Monoclonal Antibody MetMAb
MetMAb
OA-5D5
Onartuzumab
ONARTUZUMAB
PRO 143966

External Source Codes: 
CAS Registry Number 1133766-06-9 (see NLM ChemIDplus info)
FDA UNII Code MS1J9720WC
PDQ Closed Trial Search ID 639516
PDQ Open Trial Search ID 639516 (check for NCI PDQ open clinical trial info)
UMLS CUI C2826110

Other Properties:
Name Value (qualifiers indented underneath)
code C82348
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Anti-MET_Monoclonal_Antibody_MetMAb
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C82348

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