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Version: 17.06d (Release date: 2017-06-26)
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Alpha-1-Proteinase Inhibitor Human (Code C82258)

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Terms & Properties

Preferred Name: Alpha-1-Proteinase Inhibitor Human

Definition: Human serum-derived alpha-1 proteinase inhibitor (alpha-1-antitrypsin or AAT) with immunomodulating and anti-inflammatory activity. Upon administration, AAT reduces the production of proinflammatory cytokines, such as tumor necrosis factor-alpha, interleukin (IL)-1 beta, IL-32, IL-6, and proteinase 3, and induces the production of anti-inflammatory cytokines, such as IL-10 and the IL-1 receptor antagonist IL-1RN. This agent also downregulates heparan sulfate and reduces the expansion of cytotoxic effector T cells, interferes with the maturation of dendritic cells and increases T regulatory cells. Altogether, AAT may attenuate acute graft-versus-host disease (GvHD) and may facilitate graft acceptance and survival. In addition, AAT enhances levels of cAMP and activation of cAMP-dependent protein kinase A. AAT, a 52kD protein and serine protease inhibitor, belongs to the serpin superfamily.

Display Name: Alpha-1-Proteinase Inhibitor Human

Label: Alpha-1-Proteinase Inhibitor Human

NCI Thesaurus Code: C82258 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0795657  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Alpha-1-Proteinase Inhibitor Human
Alpha-1 Antitrypsin
Alpha 1 Antitrypsin

External Source Codes: 
CAS Registry Number 9041-92-3 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 721983
PDQ Open Trial Search ID 721983 (check for NCI PDQ open clinical trial info)
UMLS CUI C0795657

Other Properties:
     Name Value (qualifiers indented underneath)
code C82258
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Alpha-1-Proteinase_Inhibitor_Human
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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