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Version: 17.06d (Release date: 2017-06-26)
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Alpha-1-Proteinase Inhibitor Human (Code C82258)

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Terms & Properties

Preferred Name: Alpha-1-Proteinase Inhibitor Human

Definition: Human serum-derived alpha-1 proteinase inhibitor (alpha-1-antitrypsin or AAT) with immunomodulating and anti-inflammatory activity. Upon administration, AAT reduces the production of proinflammatory cytokines, such as tumor necrosis factor-alpha, interleukin (IL)-1 beta, IL-32, IL-6, and proteinase 3, and induces the production of anti-inflammatory cytokines, such as IL-10 and the IL-1 receptor antagonist IL-1RN. This agent also downregulates heparan sulfate and reduces the expansion of cytotoxic effector T cells, interferes with the maturation of dendritic cells and increases T regulatory cells. Altogether, AAT may attenuate acute graft-versus-host disease (GvHD) and may facilitate graft acceptance and survival. In addition, AAT enhances levels of cAMP and activation of cAMP-dependent protein kinase A. AAT, a 52kD protein and serine protease inhibitor, belongs to the serpin superfamily.

Display Name: Alpha-1-Proteinase Inhibitor Human

Label: Alpha-1-Proteinase Inhibitor Human

NCI Thesaurus Code: C82258 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0795657  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
.ALPHA.1-PROTEINASE INHIBITOR HUMAN
A1AT
A1PI
AAT
Alpha-1-Antiproteinase
Alpha-1-Proteinase Inhibitor Human
Alpha-1 Antitrypsin
Alpha 1 Antitrypsin
Aralast
Prolastin-C

External Source Codes: 
CAS Registry Number 9041-92-3 (see NLM ChemIDplus info)
FDA UNII Code F43I396OIS
PDQ Closed Trial Search ID 721983
PDQ Open Trial Search ID 721983 (check for NCI PDQ open clinical trial info)
UMLS CUI C0795657

Other Properties:
     Name Value (qualifiers indented underneath)
code C82258
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Alpha-1-Proteinase_Inhibitor_Human
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C82258

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