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Version: 17.06d (Release date: 2017-06-26)
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Rabusertib (Code C81937)

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Terms & Properties

Preferred Name: Rabusertib

Definition: An inhibitor of the cell cycle checkpoint kinase 2 (chk2) with potential chemopotentiating activity. Rabusertib binds to and inhibits the activity of chk2, which may prevent the repair of DNA caused by DNA-damaging agents, thus potentiating the antitumor efficacies of various chemotherapeutic agents. Chk2, an ATP-dependent serine-threonine kinase, is a key component in the DNA replication-monitoring checkpoint system and is activated by double-stranded breaks (DSBs); activated chk2 is overexpressed by a variety of cancer cell types.

Display Name: Rabusertib

Label: Rabusertib

NCI Thesaurus Code: C81937 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2825835  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-[5-bromo-4-methyl-2-S-(morpholin-2-yl-methoxy)-phenyl]-3-(5-methyl-pyrazin-2-yl)-urea
Checkpoint Kinase 2 Inhibitor LY2603618
LY2603618
Rabusertib
RABUSERTIB

External Source Codes: 
CAS Registry Number 911222-45-2 (see NLM ChemIDplus info)
FDA UNII Code 3S9L1NU6U7
PDQ Closed Trial Search ID 637612
PDQ Open Trial Search ID 637612 (check for NCI PDQ open clinical trial info)
UMLS CUI C2825835

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C18H22BrN5O3
code C81937
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name CHK2_Inhibitor_LY2603618
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C81937

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