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Version: 17.12d (Release date: 2017-12-26)
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Rabusertib (Code C81937)

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Terms & Properties

Preferred Name: Rabusertib

Definition: An inhibitor of the cell cycle checkpoint kinase 2 (chk2) with potential chemopotentiating activity. Rabusertib binds to and inhibits the activity of chk2, which may prevent the repair of DNA caused by DNA-damaging agents, thus potentiating the antitumor efficacies of various chemotherapeutic agents. Chk2, an ATP-dependent serine-threonine kinase, is a key component in the DNA replication-monitoring checkpoint system and is activated by double-stranded breaks (DSBs); activated chk2 is overexpressed by a variety of cancer cell types.

Display Name: Rabusertib

Label: Rabusertib

NCI Thesaurus Code: C81937 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2825835  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Checkpoint Kinase 2 Inhibitor LY2603618

External Source Codes: 
CAS Registry Number 911222-45-2 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 637612
PDQ Open Trial Search ID 637612 (check for NCI PDQ open clinical trial info)
UMLS CUI C2825835

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C18H22BrN5O3
code C81937
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name CHK2_Inhibitor_LY2603618
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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