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Version: 17.06d (Release date: 2017-06-26)
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Folate Receptor-Targeted Vinca Alkaloid EC0489 (Code C81935)

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Terms & Properties

Preferred Name: Folate Receptor-Targeted Vinca Alkaloid EC0489

Definition: A folate receptor-targeting cytotoxic drug conjugate consisting of a folate vitamin analogue linked to a vinca alkaloid microtubule destabilizing agent with potential antineoplastic activity. Mediated through its folate moiety, folate receptor-targeted vinca alkaloid EC0489 delivers the cytotoxic vinca alkaloid moiety directly to cells expressing folic acid receptors, frequently upregulated in many types of tumor cells. After ligand-receptor internalization, the vinca alkaloid moiety binds to tubulin and disrupts microtubule assembly-disassembly dynamics, resulting in cell cycle arrest and apoptosis. The relative tumor cell specificity of this agent reduces the toxicity profile of its vinca alkaloid moiety.

Display Name: Folate Receptor-Targeted Vinca Alkaloid EC0489

Label: Folate Receptor-Targeted Vinca Alkaloid EC0489

NCI Thesaurus Code: C81935 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2830054  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
EC0489
Folate Receptor-Targeted Vinca Alkaloid EC0489

External Source Codes: 
PDQ Closed Trial Search ID 638649
PDQ Open Trial Search ID 638649 (check for NCI PDQ open clinical trial info)
UMLS CUI C2830054

Other Properties:
     Name Value (qualifiers indented underneath)
code C81935
Contributing_Source CTRP
Legacy_Concept_Name Folate_Receptor_Targeted-Microtubule_Destabilizing_Agent_EC0489
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C81935

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