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Version: 17.06d (Release date: 2017-06-26)
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Ibrutinib (Code C81934)

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Terms & Properties

Preferred Name: Ibrutinib

Definition: An orally bioavailable, small-molecule inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. Upon oral administration, ibrutinib binds to and irreversibly inhibits BTK activity, thereby preventing both B-cell activation and B-cell-mediated signaling. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is required for B cell receptor signaling, plays a key role in B-cell maturation, and is overexpressed in a number of B-cell malignancies. The expression of BTK in tumor cells is also associated with increased proliferation and survival.

Display Name: Ibrutinib

Label: Ibrutinib

NCI Thesaurus Code: C81934 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2830052  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-Propen-1-one, 1-((3R)-3-(4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo(3,4-d)pyrimidin-1-yl)-1-piperidinyl)-
BTK Inhibitor PCI-32765
CRA-032765
Ibrutinib
IBRUTINIB
Imbruvica
PCI-32765

External Source Codes: 
CAS Registry Number 936563-96-1 (see NLM ChemIDplus info)
FDA UNII Code 1X70OSD4VX
PDQ Closed Trial Search ID 638648
PDQ Open Trial Search ID 638648 (check for NCI PDQ open clinical trial info)
UMLS CUI C2830052

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C25H24N6O2
code C81934
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name BTK_Inhibitor_PCI-32765
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C81934

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