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Version: 16.11d (Release date: 2016-11-28)
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Ceftriaxone Sodium (Code C817)

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Terms & Properties

Preferred Name: Ceftriaxone Sodium

Definition: The sodium salt form of ceftriaxone, a beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Ceftriaxone binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to the second and first generation cephalosporins, ceftriaxone is more active against gram-negative bacteria and less active against gram-positive bacteria. Ceftriaxone also crosses the blood-brain barrier and reaches therapeutic concentrations in the central nervous system (CNS).

Label: Ceftriaxone Sodium

NCI Thesaurus Code: C817 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0035750  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CEFTRIAXONE SODIUM
Ceftriaxone Sodium
Rocephin

External Source Codes: 
CAS Registry Number 104376-79-6 (see NLM ChemIDplus info)
FDA UNII Code 023Z5BR09K
PDQ Closed Trial Search ID 41088
PDQ Open Trial Search ID 41088 (check for NCI PDQ open clinical trial info)
UMLS CUI C0035750

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula 2C18H16N8O7S3.4Na.7H2O
code C817
Contributing_Source FDA
Legacy_Concept_Name Ceftriaxone
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C817

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