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Version: 17.06d (Release date: 2017-06-26)
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Lenapenem (Code C81662)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Lenapenem

Definition: A broad-spectrum, carbapenem antibiotic with bactericidal activity. Lenapenem binds to penicillin binding proteins (PBPs) located on the bacterial cell wall, thereby inhibiting the final transpeptidation step in the synthesis of peptidoglycan, an essential component of the bacterial cell wall. This inhibition weakens the bacterial cell wall and leads to lytic cell death in a wide range of Gram-positive and Gram-negative aerobic and anaerobic pathogens.

Label: Lenapenem

NCI Thesaurus Code: C81662 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL474519  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(+)-(4R,5S,6S)-6-((R)-1-Hydroxyethyl)-3-(((3S,5S)-5-((R)-1-hydroxy-3-(methylamino)propyl)-3-pyrrolidinyl)thio)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic Acid
LENAPENEM
Lenapenem

External Source Codes: 
CAS Registry Number 149951-16-6 (see NLM ChemIDplus info)
FDA UNII Code D6NBQ3H12U
PDQ Closed Trial Search ID 761707
PDQ Open Trial Search ID 761707 (check for NCI PDQ open clinical trial info)
NCI META CUI CL474519

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C18H29N3O5S
code C81662
Contributing_Source FDA
Legacy_Concept_Name Lenapenem
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C81662

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