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Version: 16.11d (Release date: 2016-11-28)
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Gadofosveset Trisodium (Code C81057)

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Terms & Properties

Preferred Name: Gadofosveset Trisodium

Definition: The trisodium salt form of gadofosveset, an injectable, intravascular, amphiphilic gadolinium-based contrast agent (GBCA) used with magnetic resonance angiography (MRA) imaging. Gadofosveset is a stable gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) chelate derivative with a diphenylcyclohexylphosphate group. Upon injection, gadofosveset binds reversibly to endogenous serum albumin which increases its intravascular retention time compared to non-protein binding contrast agents. The serum albumin binding also increases T1-relaxivity of gadofosveset. This produces an increase in signal intensity of blood, thereby enhancing the visualization of blood vessels upon MRA and may aid in the diagnosis of certain blood vessels and heart disorders.

Display Name: Gadofosveset Trisodium

Label: Gadofosveset Trisodium

NCI Thesaurus Code: C81057 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1433439  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ablavar
Gadofosveset Trisodium
GADOFOSVESET TRISODIUM
MS-325
Vasovist

External Source Codes: 
CAS Registry Number 211570-55-7 (see NLM ChemIDplus info)
FDA UNII Code XM33Q67UVH
PDQ Closed Trial Search ID 712739
PDQ Open Trial Search ID 712739 (check for NCI PDQ open clinical trial info)
UMLS CUI C1433439

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C33H38N3O14P.Gd.3Na.H2O
code C81057
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Gadofosveset_Trisodium
Semantic_Type Indicator, Reagent, or Diagnostic Aid
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C81057

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