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Version: 17.06d (Release date: 2017-06-26)
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Calfactant (Code C80989)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Calfactant

Definition: A sterile suspension composed of an extract of bovine pulmonary surfactant with surfactant activity. Calfactant contains phospholipids, neutral lipids, and hydrophobic surfactant-associated proteins B (SP-B) and C (SP-C). Upon intratracheal administration, this agent, mimicking endogenous pulmonary surfactant, lines the alveoli and smallest bronchioles, keeping alveoli open during expiration by lowering surface tension. Resulting improvements in lung compliance and respiratory gas exchange may lead to improvements in ventilation and oxygenation.

Label: Calfactant

NCI Thesaurus Code: C80989 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0763530  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CALFACTANT
Calfactant
Infasurf
Infasurf Intratracheal Suspension

External Source Codes: 
CAS Registry Number 183325-78-2 (see NLM ChemIDplus info)
FDA UNII Code Q4K217VGA9
PDQ Closed Trial Search ID 658431
PDQ Open Trial Search ID 658431 (check for NCI PDQ open clinical trial info)
UMLS CUI C0763530

Other Properties:
     Name Value (qualifiers indented underneath)
code C80989
Contributing_Source FDA
Legacy_Concept_Name Calfactant
Semantic_Type Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C80989

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