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Version: 17.12d (Release date: 2017-12-26)
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Talabostat Mesylate (Code C80682)

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Terms & Properties

Preferred Name: Talabostat Mesylate

Definition: The mesylate salt of an orally active small molecule with antineoplastic and hematopoiesis- stimulating activities. By cleaving N-terminal Xaa-Pro or Xaa-Ala residues, talabostat inhibits dipeptidyl peptidases, such as fibroblast activation protein (FAP), resulting in the stimulation of cytokine and chemokine production and specific T-cell immunity and T-cell dependent activity. This agent may also stimulate the production of colony stimulating factors, such as granulocyte colony stimulating factor (G-CSF), resulting in the stimulation of hematopoiesis. Dipeptidyl peptidases are involved in the activation of polypeptide hormones and chemokines.

NCI-GLOSS Definition: A substance being studied in the treatment of cancer, including certain types of lung, pancreas, and brain cancer. Talabostat mesylate may help the immune system block the growth of cancer cells. It may also increase the growth of new blood cells. It is a type of enzyme inhibitor.

Label: Talabostat Mesylate

NCI Thesaurus Code: C80682 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1311786  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
((2R)-1-((2S)-2-amino-3-methylbutanoyl)pyrrolidin-2-yl)boronic Acid Methanesulfonate
Talabostat Mesylate
talabostat mesylate

External Source Codes: 
CAS Registry Number 150080-09-4 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 372906
PDQ Open Trial Search ID 372906 (check for NCI PDQ open clinical trial info)
UMLS CUI C1311786

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C9H19BN2O3.CH4O3S
code C80682
Contributing_Source FDA
Legacy_Concept_Name Talabostat_Mesylate
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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