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Version: 17.06d (Release date: 2017-06-26)
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Sotrastaurin Acetate (Code C80631)

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Terms & Properties

Preferred Name: Sotrastaurin Acetate

Definition: The acetate salt form of sotrastaurin, an orally available pan-protein kinase C (PKC) inhibitor with potential immunosuppressive and antineoplastic activities. Sotrastaurin inhibits both T- and B-cell activations via PKC theta and beta isozymes, respectively. Both PKCs are important in the activation of nuclear factor-kappaB (NF-kB). Inhibition of PKC beta in B-cells results in prevention of NF-kB-mediated signaling and down regulation of NF-kB target genes. This may eventually lead to an induction of G1 cell cycle arrest and tumor cell apoptosis in susceptible tumor cells. This agent may act synergistically with other chemotherapeutic agents. PKC, a family of serine/threonine protein kinases overexpressed in certain types of cancer cells, is involved in cell differentiation, mitogenesis, inflammation, and the activation and survival of lymphocytes.

Display Name: Sotrastaurin Acetate

Label: Sotrastaurin Acetate

NCI Thesaurus Code: C80631 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2830197  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4- yl)-1H-pyrrole-2,5-dione Acetate
AEB071
AEB 071
Sotrastaurin Acetate
SOTRASTAURIN ACETATE

External Source Codes: 
CAS Registry Number 908351-31-5 (see NLM ChemIDplus info)
FDA UNII Code R1SIA15KZ1
PDQ Closed Trial Search ID 708113
PDQ Open Trial Search ID 708113 (check for NCI PDQ open clinical trial info)
UMLS CUI C2830197

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C25H22N6O2.C2H4O2
code C80631
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Sotrastaurin_Acetate
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C80631

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