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Version: 17.06d (Release date: 2017-06-26)
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TLR8 Agonist VTX-2337 (Code C80521)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: TLR8 Agonist VTX-2337

Definition: A small-molecule Toll-like receptor 8 (TLR8) agonist with potential immunostimulating and antineoplastic activities. TLR8 agonist VTX-2337 binds to TLR8, present in cutaneous dendritic cells, monocytes/macrophages, and mast cells, which may result in the activation of the central transcription factor nuclear factor-B, the secretion of proinflammatory cytokines and other mediators, and a Th1-weighted antitumoral cellular immune response. Primarily localized to endosomal membranes intracellularly, TLR8, like other TLRs, recognizes pathogen-associated molecular patterns (PAMPs) and plays a key role in the innate immune system.

Display Name: TLR8 Agonist VTX-2337

Label: TLR8 Agonist VTX-2337

NCI Thesaurus Code: C80521 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2825237  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
TLR8 Agonist VTX-2337
Toll-like Receptor 8 Agonist VTX-2337
VTX-2337

External Source Codes: 
PDQ Closed Trial Search ID 599455
PDQ Open Trial Search ID 599455 (check for NCI PDQ open clinical trial info)
UMLS CUI C2825237

Other Properties:
     Name Value (qualifiers indented underneath)
code C80521
Contributing_Source CTRP
Legacy_Concept_Name TLR8_Agonist_VTX-2337
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C80521

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