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Version: 17.08d (Release date: 2017-08-28)
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Razoxane (Code C801)

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Terms & Properties

Preferred Name: Razoxane

Definition: An orally bioavailable bis-dioxopiperazine and a derivative of the chelating agent ethylenediaminetetraacetic acid (EDTA) with antineoplastic, antiangiogenic, and antimetastatic activities. Razoxane specifically inhibits the enzyme topoisomerase II without inducing DNA strand breaks, which may result in the inhibition of DNA synthesis and cell division in the premitotic and early mitotic phases of the cell cycle. This agent may also exhibit antiangiogenic and antimetastatic activities although the precise molecular mechanisms of these actions are unknown.

Label: Razoxane

NCI Thesaurus Code: C801 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0034738  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ICI 59118
ICRF 159

External Source Codes: 
CAS Registry Number 21416-87-5 (see NLM ChemIDplus info)
CAS Registry Number 21416-67-1 (see NLM ChemIDplus info)
FDA UNII Code 5AR83PR647
ChEBI ID CHEBI:50225 (see ChEBI info)
NSC Code 129943 (see NCI DTP info)
PDQ Closed Trial Search ID 39480
PDQ Open Trial Search ID 39480 (check for NCI PDQ open clinical trial info)
UMLS CUI C0034738

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C11H16N4O4
code C801
Contributing_Source FDA
Legacy_Concept_Name Razoxane
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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