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Version: 16.10e (Release date: 2016-10-31)
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Fentanyl Matrix Transdermal Patch (Code C80067)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Fentanyl Matrix Transdermal Patch

Definition: A transdermal formulation containing the synthetic phenylpiperidine opioid agonist fentanyl, with analgesic activity. Upon topical administration, fentanyl diffuses from the transdermal patch through the skin, is transported via the systemic circulation, and selectively binds to the mu-receptor in the central nervous system (CNS), mimicking the effects of endogenous opiates. Stimulation of the mu-receptor inhibits adenyl cyclase activity, induces opening of G-protein-coupled inwardly rectifying potassium (GIRK) channels, and blocks the opening of N-type voltage-gated calcium channels, resulting in hyperpolarization and reduced neuronal excitability; in addition, neuronal release of neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline may decrease.

Label: Fentanyl Matrix Transdermal Patch

NCI Thesaurus Code: C80067 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL388406  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Durogesic DTrans
Fentanyl Matrix Transdermal Delivery System
Fentanyl Matrix Transdermal Patch

External Source Codes: 
PDQ Closed Trial Search ID 617992
PDQ Open Trial Search ID 617992 (check for NCI PDQ open clinical trial info)
NCI META CUI CL388406

Other Properties:
Name Value (qualifiers indented underneath)
code C80067
Legacy_Concept_Name Fentanyl_Matrix_Transdermal_Patch
Semantic_Type Chemical Viewed Functionally
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C80067

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