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Version: 17.06d (Release date: 2017-06-26)
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Topotecan Hydrochloride Liposomes (Code C80065)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Topotecan Hydrochloride Liposomes

Definition: The hydrochloride salt of a semisynthetic derivative of camptothecin mixed with sphingomyelin/cholesterol and sonicated to form small unilamellar vesicles containing topotecan, with potential antineoplastic activity. Topotecan hydrochloride liposomes mediates efficient drug delivery of topotecan into the cytosol from the endosome compartment. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery.

Display Name: Topotecan Hydrochloride Liposomes

Label: Topotecan Hydrochloride Liposomes

NCI Thesaurus Code: C80065 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL388400  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Brakiva
Topotecan Hydrochloride Liposomes

External Source Codes: 
PDQ Closed Trial Search ID 617377
PDQ Open Trial Search ID 617377 (check for NCI PDQ open clinical trial info)
NCI META CUI CL388400

Other Properties:
     Name Value (qualifiers indented underneath)
code C80065
Contributing_Source CTRP
Legacy_Concept_Name Topotecan_Hydrochloride_Liposomes
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C80065

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