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Version: 17.06d (Release date: 2017-06-26)
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Retinoid 9cUAB30 (Code C80061)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Retinoid 9cUAB30

Definition: A synthetic analogue of 9-cis retinoic acid with potential antineoplastic and chemopreventive activities. Retinoid 9cUAB30 binds to and activates retinoid X receptor (RXR) homodimers and/or and retinoic acid receptor (RAR)/RXR heterodimers, which may result in the dissociation of corepressor protein and the recruitment of coactivator protein, followed by transcription of downstream target genes into mRNAs and protein translation. Gene transcription regulated by these transcription factors may result in inhibition of cell proliferation, induction of cell differentiation, and apoptosis of both normal cells and tumor cells.

NCI-GLOSS Definition: A substance being studied in the treatment and prevention of cancer. It blocks an enzyme that keeps cells alive by adding material to the ends of chromosomes. Blocking this enzyme may cause the cancer cells to die. 9cUAB30 is a type of retinoic acid and a type of telomerase inhibitor.

Display Name: Retinoid 9cUAB30

Label: Retinoid 9cUAB30

NCI Thesaurus Code: C80061 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1311390  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
9cUAB30
Retinoid 9cUAB30

External Source Codes: 
PDQ Closed Trial Search ID 614594
PDQ Open Trial Search ID 614594 (check for NCI PDQ open clinical trial info)
UMLS CUI C1311390

Other Properties:
     Name Value (qualifiers indented underneath)
code C80061
Contributing_Source CTRP
Legacy_Concept_Name Retinoid_9cUAB30
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C80061

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