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Version: 17.06d (Release date: 2017-06-26)
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Raf/MEK Serine/Threonine Kinase Inhibitor RO5126766 (Code C80060)

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Terms & Properties

Preferred Name: Raf/MEK Serine/Threonine Kinase Inhibitor RO5126766

Definition: A protein kinase inhibitor specific for the Raf and MEK mitogen-activated protein kinases (MAPKs) with potential anti-neoplastic activity. Raf/MEK dual kinase Inhibitor RO5126766 specifically inhibits the kinase activities of Raf and MEK, resulting in the inhibition of target gene transcription that promotes malignant transformation of cells. Both Raf and MEK are serine/threonine-specific kinases that respond to extracellular stimuli, such as mitogens, and are involved in the regulation of cellular processes, such as gene expression, mitosis, differentiation, and apoptosis.

Label: Raf/MEK Serine/Threonine Kinase Inhibitor RO5126766

NCI Thesaurus Code: C80060 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2703210  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Raf/MEK Serine/Threonine Kinase Inhibitor RO5126766
RO5126766

External Source Codes: 
PDQ Closed Trial Search ID 618692
PDQ Open Trial Search ID 618692 (check for NCI PDQ open clinical trial info)
UMLS CUI C2703210

Other Properties:
     Name Value (qualifiers indented underneath)
code C80060
Legacy_Concept_Name Raf_MEK_Serine_Threonine_Kinase_Inhibitor_RO5126766
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C80060

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