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Version: 17.06d (Release date: 2017-06-26)
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Niraparib (Code C80059)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Niraparib

Definition: An orally bioavailable inhibitor of poly (ADP-ribose) polymerase (PARP) types 1 and 2 (PARP-1 and -2), with antineoplastic activity. Upon administration, niraparib binds to and inhibits the activity of PARP-1 and -2, thereby inhibiting PARP-1 and -2-mediated DNA repair, enhancing the accumulation of DNA strand breaks, promoting genomic instability and resulting in apoptosis. The PARP family of proteins catalyzes post-translational ADP-ribosylation of nuclear proteins and is activated by single-strand DNA (ssDNA) breaks.

Display Name: Niraparib

Label: Niraparib

NCI Thesaurus Code: C80059 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2744440  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
MK-4827
MK4827
Niraparib
NIRAPARIB

External Source Codes: 
CAS Registry Number 1038915-60-4 (see NLM ChemIDplus info)
FDA UNII Code HMC2H89N35
PDQ Closed Trial Search ID 615263
PDQ Open Trial Search ID 615263 (check for NCI PDQ open clinical trial info)
UMLS CUI C2744440

Other Properties:
     Name Value (qualifiers indented underneath)
code C80059
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name PARP_Inhibitor_MK4827
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C80059

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