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Version: 17.12d (Release date: 2017-12-26)
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Niraparib (Code C80059)

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Terms & Properties

Preferred Name: Niraparib

Definition: An orally bioavailable inhibitor of poly (ADP-ribose) polymerase (PARP) types 1 and 2 (PARP-1 and -2), with antineoplastic activity. Upon administration, niraparib binds to and inhibits the activity of PARP-1 and -2, thereby inhibiting PARP-1 and -2-mediated DNA repair, enhancing the accumulation of DNA strand breaks, promoting genomic instability and resulting in apoptosis. The PARP family of proteins catalyzes post-translational ADP-ribosylation of nuclear proteins and is activated by single-strand DNA (ssDNA) breaks.

Display Name: Niraparib

Label: Niraparib

NCI Thesaurus Code: C80059 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2744440  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
CAS Registry Number 1038915-60-4 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 615263
PDQ Open Trial Search ID 615263 (check for NCI PDQ open clinical trial info)
UMLS CUI C2744440

Other Properties:
     Name Value (qualifiers indented underneath)
code C80059
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name PARP_Inhibitor_MK4827
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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