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Version: 17.06d (Release date: 2017-06-26)
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Foretinib (Code C80058)

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Terms & Properties

Preferred Name: Foretinib

Definition: An orally bioavailable small molecule with potential antineoplastic activity. Foretinib binds to and selectively inhibits hepatocyte growth factor (HGF) receptor c-MET and vascular endothelial growth factor receptor 2 (VEGFR2), which may result in the inhibition of tumor angiogenesis, tumor cell proliferation and metastasis. The proto-oncogene c-MET has been found to be over-expressed in a variety of cancers. VEGFR2 is found on endothelial and hematopoietic cells and mediates the development of the vasculature and hematopoietic cells through VEGF signaling.

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. Foretinib blocks enzymes involved in the growth and spread of tumor cells. It may also prevent the growth of new blood vessels that tumors need to grow. It is a type of tyrosine kinase inhibitor and a type of antiangiogenesis agent.

Display Name: Foretinib

Label: Foretinib

NCI Thesaurus Code: C80058 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2698272  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Foretinib
FORETINIB
foretinib
GSK1363089
MET/VEGFR-2 inhibitor GSK1363089
Multitargeted Tyrosine Kinase Inhibitor GSK1363089
N-(3-Fluoro-4-((6-methoxy-7-(3-(morpholin-4-yl)propoxy)quinolin-4-yl)oxy)phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
XL880

External Source Codes: 
CAS Registry Number 849217-64-7 (see NLM ChemIDplus info)
FDA UNII Code 81FH7VK1C4
PDQ Closed Trial Search ID 428188
PDQ Open Trial Search ID 428188 (check for NCI PDQ open clinical trial info)
UMLS CUI C2698272

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C34H34F2N4O6
code C80058
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Multitargeted_Tyrosine_Kinase_Inhibitor_GSK1363089
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C80058

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