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Version: 17.06d (Release date: 2017-06-26)
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Ioflubenzamide I-131 (Code C80056)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Ioflubenzamide I-131

Definition: An iodine 131-radiolabeled small-molecule benzamide compound with potential antineoplastic activity. The benzamide moiety of 131-I-MIP-1145 binds to melanin, selectively delivering a cyotoxic dose of gamma and beta radiation to melanin-expressing tumor cells. Melanin pigments, polymer derivatives of the amino acid tyrosine, are over-expressed in approximately 40% of melanomas.

Label: Ioflubenzamide I-131

NCI Thesaurus Code: C80056 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2934646  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
IOFLUBENZAMIDE I-131
Ioflubenzamide I-131
MIP-1145
N-(2-(diethylamino)ethyl)-4-((4-fluorobenzoyl)amino)-5-((sup 131)I)iodo-2-methoxybenzamide

External Source Codes: 
CAS Registry Number 1214283-52-9 (see NLM ChemIDplus info)
FDA UNII Code 65O1D58Z6V
PDQ Closed Trial Search ID 615097
PDQ Open Trial Search ID 615097 (check for NCI PDQ open clinical trial info)
UMLS CUI C2934646

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C21H25FIN3O3
code C80056
Contributing_Source FDA
Legacy_Concept_Name Iodine_I_131_MIP-1145
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C80056

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