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Version: 17.06d (Release date: 2017-06-26)
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Cyclosporine Ophthalmic Emulsion (Code C80051)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Cyclosporine Ophthalmic Emulsion

Definition: An topical ophthalmic formulation containing cyclosporine, an undecapeptide produced by the fungus Beauveria nivea, with immunosuppressant and anti-inflammatory activities. The exact therapeutic mechanism of action of cyclosporine is not known but may involve binding to the cellular protein cytophilin, resulting in inhibition of the enzyme calcineurin. This agent appears to specifically and reversibly inhibit immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially inhibited with T-helper cells as the primary target. Cyclosporine also inhibits lymphokine production and release.

Display Name: Cyclosporine Ophthalmic Emulsion

Label: Cyclosporine Ophthalmic Emulsion

NCI Thesaurus Code: C80051 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1170584  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Cyclosporine Ophthalmic Emulsion
Restasis

External Source Codes: 
PDQ Closed Trial Search ID 614830
PDQ Open Trial Search ID 614830 (check for NCI PDQ open clinical trial info)
UMLS CUI C1170584

Other Properties:
     Name Value (qualifiers indented underneath)
code C80051
Contributing_Source CTRP
Legacy_Concept_Name Cyclosporine_Ophthalmic_Emulsion
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C80051

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