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Version: 17.06d (Release date: 2017-06-26)
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CDK4 Inhibitor P1446A-05 (Code C80049)

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Terms & Properties

Preferred Name: CDK4 Inhibitor P1446A-05

Definition: A protein kinase inhibitor specific for the cyclin-dependent kinase 4 (CDK4) with potential antineoplastic activity. CDK4 inhibitor P1446A-05 specifically inhibits CDK4-mediated G1-S phase transition, arresting cell cycling and inhibiting cancer cell growth. The serine/threonine kinase CDK4 is found in a complex with D-type G1 cyclins and is the first kinase to become activated upon mitogenic stimulation, releasing cells from a quiescent stage into the G1/S growth cycling stage; CDK-cyclin complexes have been shown to phosphorylate the retinoblastoma (Rb) transcription factor in early G1, displacing histone deacetylase (HDAC) and blocking transcriptional repression.

Display Name: CDK4 Inhibitor P1446A-05

Label: CDK4 Inhibitor P1446A-05

NCI Thesaurus Code: C80049 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL388407  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CDK4 Inhibitor P1446A-05

External Source Codes: 
PDQ Closed Trial Search ID 618682
PDQ Open Trial Search ID 618682 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C80049
Contributing_Source CTRP
Legacy_Concept_Name CDK4_Serine_Threonine_Kinase_Inhibitor_P1446A-05
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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