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Version: 17.06d (Release date: 2017-06-26)
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Camptothecin Analogue TLC388 (Code C80047)

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Terms & Properties

Preferred Name: Camptothecin Analogue TLC388

Definition: A synthetic analogue of camptothecin with potential antineoplastic and radio-sensitizing activities. Camptothecin analogue TLC388 selectively stabilizes topoisomerase I-DNA covalent complexes during S-phase, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. Topoisomerase I relaxes negative super-coiled DNA during replication and transcription. This agent has been chemically modified to enhance the potency and stability of camptothecin.

Display Name: Camptothecin Analogue TLC388

Label: Camptothecin Analogue TLC388

NCI Thesaurus Code: C80047 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2703206  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Camptothecin Analogue TLC388
Lipotecan
TLC388

External Source Codes: 
PDQ Closed Trial Search ID 615096
PDQ Open Trial Search ID 615096 (check for NCI PDQ open clinical trial info)
UMLS CUI C2703206

Other Properties:
     Name Value (qualifiers indented underneath)
code C80047
Contributing_Source CTRP
Legacy_Concept_Name Camptothecin_Analogue_TLC388
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C80047

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