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Version: 16.10e (Release date: 2016-10-31)
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B16alphaGal Melanoma Vaccine (Code C80046)

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Terms & Properties

Preferred Name: B16alphaGal Melanoma Vaccine

Definition: A whole cell melanoma cancer vaccine with potential immunostimulating and antineoplastic activities. B16alphaGal melanoma vaccine contains three types of human melanoma cell lines that are genetically engineered to express the alpha(1,3)-galactosyl (alphaGal) epitope on cell surfaces. The agent stimulates a hyperacute rejection of whole melanoma cancer cells expressing alphaGal epitopes, initiated by opsonization by anti-alphaGal antibodies and followed by antibody-dependent cell-mediated cytotoxicity (ADCC) and cell lysis. This results in the stimulation of a broader cytotoxic T-lymphocyte response (CTL) directed against tumor antigens on melanoma cells that do not express alphaGal. AlphaGal is not normally expressed in humans because alpha(1,3)-galactosyltransferase (Alpha-GT), the enzyme that catalyzes the synthesis of alphaGal epitopes on glycoproteins and glycolipids, is not naturally present in humans and other primates.

Display Name: B16alphaGal Melanoma Vaccine

Label: B16alphaGal Melanoma Vaccine

NCI Thesaurus Code: C80046 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL388386  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
B16alphaGal Melanoma Vaccine
Hyperacute Melanoma

External Source Codes: 
PDQ Closed Trial Search ID 615145
PDQ Open Trial Search ID 615145 (check for NCI PDQ open clinical trial info)
NCI META CUI CL388386

Other Properties:
Name Value (qualifiers indented underneath)
code C80046
Contributing_Source CTRP
Legacy_Concept_Name B16alphaGal_Melanoma_Vaccine
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C80046

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