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Version: 17.06d (Release date: 2017-06-26)
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Sotatercept (Code C80038)

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Terms & Properties

Preferred Name: Sotatercept

Definition: A soluble fusion protein composed of the extracellular domain of the activin receptor type IIA (ActRIIA) linked to the Fc portion of human IgG1 with anabolic bone activity. Sotatercept selectively binds to activin, inhibiting its binding to ActRIIA and ActRIIA signaling, resulting in the stimulation of osteoblast activity and the inhibition of osteoclast activity and so normal bone formation and increased bone mineral density and strength. The Fc moiety of this fusion protein binds to the salvage receptor FcRN, preventing its lysosomal degradation and so extending its half-life in the circulatory system.

Display Name: Sotatercept

Label: Sotatercept

NCI Thesaurus Code: C80038 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2703199  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ACE-011
Decoy Activin Receptor ACE-011
Sotatercept
SOTATERCEPT

External Source Codes: 
CAS Registry Number 1001080-50-7 (see NLM ChemIDplus info)
FDA UNII Code 0QI90BTJ37
PDQ Closed Trial Search ID 615188
PDQ Open Trial Search ID 615188 (check for NCI PDQ open clinical trial info)
UMLS CUI C2703199

Other Properties:
     Name Value (qualifiers indented underneath)
code C80038
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Decoy_Activin_Receptor_ACE-011
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C80038

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