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Version: 16.11d (Release date: 2016-11-28)
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2'-F-ara-deoxyuridine (Code C80036)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: 2'-F-ara-deoxyuridine

Definition: A deoxyuridine prodrug with potential antineoplastic activity. Upon cellular uptake, 2'-F-ara-deoxyuridine (FAU) is phosphorylated by thymidine kinase to FAU monophosphate and subsequently methylated in the 5'-position by thymidylate synthase (TS) to its activated form, 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) 5-methyluracil monophosphate (FMAUMP). FMAUMP is incorporated into DNA leading to an inhibition of DNA synthesis and so cell growth. The catalytic activity of TS is critical to activation of FAU and subsequent incorporation into DNA. FAU may be beneficial in the case of tumors with high TS activity that are resistant to TS inhibitors.

NCI-GLOSS Definition: A substance being studied in the treatment of advanced solid tumors and lymphomas. It blocks the growth of cells and may cause cancer cells to die. It is a type of uracil analog.

Display Name: 2'-F-ara-deoxyuridine

Label: 2'-F-ara-deoxyuridine

NCI Thesaurus Code: C80036 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL388502  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl) Uracil
1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl) uracil
1-(2-DEOXY-2-FLUORO-.BETA.-D-ARABINOFURANOSYL)URACIL
2'-F-ara-deoxyuridine
FAU

External Source Codes: 
CAS Registry Number 69123-94-0 (see NLM ChemIDplus info)
FDA UNII Code K7386OMP29
PDQ Closed Trial Search ID 616102
PDQ Open Trial Search ID 616102 (check for NCI PDQ open clinical trial info)
NCI META CUI CL388502

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C9H11FN2O5
code C80036
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name _2-F-ara-deoxyuridine
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C80036

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