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Version: 16.10e (Release date: 2016-10-31)
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CHK1 Inhibitor MK-8776 (Code C79867)

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Terms & Properties

Preferred Name: CHK1 Inhibitor MK-8776

Definition: An agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. Chk1 inhibitor MK-8776 specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents. Chk1 is an ATP-dependent serine-threonine kinase that in response to DNA damage phosphorylates cdc25 phosphatases, resulting in inhibitory tyrosine phosphorylation of CDK-cyclin complexes and cell cycle arrest.

Display Name: CHK1 Inhibitor MK-8776

Label: CHK1 Inhibitor MK-8776

NCI Thesaurus Code: C79867 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2703183  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(R)-6-Bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine
CHK1 Inhibitor MK-8776
MK-8776
MK8776
SCH-900776
SCH 900776

External Source Codes: 
CAS Registry Number 891494-63-6 (see NLM ChemIDplus info)
FDA UNII Code K2ZSF0992C
PDQ Closed Trial Search ID 624396
PDQ Open Trial Search ID 624396 (check for NCI PDQ open clinical trial info)
UMLS CUI C2703183

Other Properties:
Name Value (qualifiers indented underneath)
code C79867
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name CHK1_Inhibitor_SCH_900776
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C79867

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