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Version: 17.08d (Release date: 2017-08-28)
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CHK1 Inhibitor MK-8776 (Code C79867)

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Terms & Properties

Preferred Name: CHK1 Inhibitor MK-8776

Definition: An agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. Chk1 inhibitor MK-8776 specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents. Chk1 is an ATP-dependent serine-threonine kinase that in response to DNA damage phosphorylates cdc25 phosphatases, resulting in inhibitory tyrosine phosphorylation of CDK-cyclin complexes and cell cycle arrest.

Display Name: CHK1 Inhibitor MK-8776

Label: CHK1 Inhibitor MK-8776

NCI Thesaurus Code: C79867 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2703183  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CHK1 Inhibitor MK-8776
SCH 900776

External Source Codes: 
CAS Registry Number 891494-63-6 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 624396
PDQ Open Trial Search ID 624396 (check for NCI PDQ open clinical trial info)
UMLS CUI C2703183

Other Properties:
     Name Value (qualifiers indented underneath)
code C79867
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name CHK1_Inhibitor_SCH_900776
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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