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Version: 17.06d (Release date: 2017-06-26)
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MEK-1/MEKK-1 Inhibitor E6201 (Code C79848)

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Terms & Properties

Preferred Name: MEK-1/MEKK-1 Inhibitor E6201

Definition: A synthetic, fungal metabolite analogue inhibitor of mitogen-activated protein kinase kinase 1 (MEK-1) and mitogen-activated protein kinase kinase kinase 1 (MEKK-1) with potential antipsoriatic and antineoplastic activities. MEK-1/MEKK-1 inhibitor E6201 specifically binds to and inhibits the activities of MEK-1 and MEKK-1, which may result in the inhibition of tumor cell proliferation. MEK-1 and MEKK-1 are key components in the RAS/RAF/MEK/MAPK signaling pathway, which regulates cell proliferation and is frequently activated in human cancers.

Display Name: MEK-1/MEKK-1 Inhibitor E6201

Label: MEK-1/MEKK-1 Inhibitor E6201

NCI Thesaurus Code: C79848 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL388442  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
E6201
MEK-1/MEKK-1 Inhibitor E6201

External Source Codes: 
PDQ Closed Trial Search ID 629676
PDQ Open Trial Search ID 629676 (check for NCI PDQ open clinical trial info)
NCI META CUI CL388442

Other Properties:
     Name Value (qualifiers indented underneath)
code C79848
Contributing_Source CTRP
Legacy_Concept_Name MEK-1_MEKK-1_Tyrosine_Kinase_Inhibitor_E6201
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C79848

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