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Version: 17.12d (Release date: 2017-12-26)
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Volasertib (Code C79844)

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Terms & Properties

Preferred Name: Volasertib

Definition: A dihydropteridinone Polo-like kinase 1 (Plk1) inhibitor with potential antineoplastic activity. Volasertib selectively inhibits Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner.

Display Name: Volasertib

Label: Volasertib

NCI Thesaurus Code: C79844 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2703181  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Benzamide, N-(Trans-4-(4-(Cyclopropylmethyl)-1-Piperazinyl)Cyclohexyl)-4-(((7r)-7-Ethyl-5,6,7,8-Tetrahydro-5-Methyl-8-(1-Methylethyl)-6-Oxo-2-Pteridinyl)Amino)-3-Methoxy-
BI 6727
Polo-like Kinase 1 Inhibitor BI 6727

External Source Codes: 
CAS Registry Number 755038-65-4 (see NLM ChemIDplus info)
FDA UNII Code 6EM57086EA
PDQ Closed Trial Search ID 630756
PDQ Open Trial Search ID 630756 (check for NCI PDQ open clinical trial info)
UMLS CUI C2703181

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C34H50N8O3
code C79844
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Polo-like_Kinase_1_Inhibitor_BI_6727
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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